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Aug 06, 2026
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BIOT 239 - Biomaterials and Tissue Engineering
PREREQUISITES: BIOT 201 - Cell Culture & Cell Processes
PROGRAM: Biotechnology
CREDIT HOURS MIN: 4
LECTURE HOURS MIN: 2
LAB HOURS MIN: 4
DATE OF LAST REVISION: Summer, 2011
The student will be introduced to biomaterial and tissue functionality and design including the basic concepts underlying physiological responses to wounds and foreign materials. Topics to be considered include biomaterial scaffolds, relevant cell types, soluble regulators or their genes, and mechanical loading and culture conditions. Comparisons will be made between differentiated cell types and stem cells as well as natural and synthetic scaffolds. Methodology for the preparation of cells and scaffolds in practice is described. The rationale for employing growth factors is covered and the techniques for gene modification for optimizing matrix interactions are discussed. Methods for fabricating tissue- engineered products and devices for implantation are taught including material selection and processing, mechanisms of material degradation, cell-material interactions and interfaces, matrix structure transport issues. Examples of tissue engineering -based procedures currently employed clinically are analyzed as case studies. Students will gain experience with biomaterial design and modification in addition to cell culture with these matrices.
MAJOR COURSE LEARNING OBJECTIVES: Upon successful completion of this course the student will be expected to:
- Know the important parameters underlying biomaterial design and tissue engineering.
- Understand the process of tissue growth and development in vitro and in vivo.
- Be familiar with theoretical design of tissues and organs.
- Understand stem cells, including adult and embryonic stem cells and progenitor populations.
- Be familiar with adult and embryonic stem cells of the cardiovascular, hematopoietic, musculoskeletal, nervous, and other organ systems.
- Recognize the differentiation and dedifferentiation processes and apply this understanding to genetic modifications that enable native tissue formulation.
- Be familiar with the opportunities for tissue engineering therapies for heart disease, diabetes, and a wide variety of other diseases that afflict humanity.
- Understand the importance of biomaterial-protein interactions and methods of empirical study.
- Be familiar with nanocomposite and three-dimensional scaffold biomaterials.
- Demonstrate biomaterial testing methods and importance in vivo.
- Know cell culture methods for tissue engineering.
- Understand methods for design of skin substitutes, spinal cord augmentation, vision enhancement, and heart valves.
- Understand tissue engineering for soft and hard tissue.
COURSE CONTENT: Topical areas of study include -
- Biomaterial design (material, tissue interface, biocompatibility)
- Tissue engineering (extracellular matrix, integrins)
- Tissue growth and development
- Design of tissues and organs
- Cell types and functions in tissues
- Tissue engineered therapies/remedies for pathologies
- Adult stem cells
- Embryonic stem cells
- Differentiation and dedifferentiation
- Enabling native tissue formulation
- Growth factors and related genes
- Biomaterial-protein interactions
- Methods of empirical study
- Bionanotechnology (implant design)
- Three dimensional scaffold formation and evaluation
- Biomaterial testing methods (mechanical, cytocompatibility, surface analysis)
- Cell culture methods pertaining to tissue engineering
- Hard and soft tissue engineering
Course Addendum - Syllabus (Click to expand)
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